Solution Used	Antimicrobial Combination	Species	Condition	Causative Organism	Therapeutic Regimen	Results	Reference
Tromethamine (TRIS)-EDTA	None	Dogs	Experimental otitis	Pseudomonas	5 ml in ear canal b.i.d. for 7 days	Effective: 46% with reduced organisms, 36% cured, 18% no response	Blue et al., 1974
TRIS-EDTA	Lysozyme with and without gentamicin	Dogs	Experimental cystitis	Pseudomonas aeruginosa	25 ml as catheter flush once daily for 14-16 days	Alone as effective as gentamicin, but allows overgrowth of staphylococci and streptococci	Wooley et al., 1974
TRIS-EDTA	Oxytetracycline	Dogs, cats	Experimental cystitis	Proteus mirabilis	Dog: 30 ml as catheter flus, b.i.d. for 7-13 days Cat: 5 ml as catheter flush, b.i.d. for 7-13 days	Resistance to tetracycline not altered	Wooley et al., 1975
TRIS-EDTA	Gentamicin	Dog (1 case)	Rhinosinusitis	Pseudomonas	3-4 drops in nostrils 6 times daily for 10 days Nebulize 6 times daily for 10 days 60 ml flush t.i.d. for 21 days	Effective: Animal cured	Wooley et al., 1979
TRIS-EDTA	Gentamicin	Dog (1 case)	Multiple fistulas from surgical wound	Pseudomonas	60 ml flush t.i.d. for 21 days	Effective: Animal cured	Bjorling and Wooley, 1982

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