Effect of chlorhexidene/EDTA/Tris against bacterial isolates from clinical specimens

Harper WE, Epis JA
Department of Microbiology, Royal Perth Hospital, Western Australia

Micorobios. 1987;51(207):107-12.

chlorhexidene/EDTA/Tris was more active compared with chlorhexidene against the following species of organisms: Acinetobacter species, Citrobacter species, Enterobacter species, Escherichia coli, Proteus mirabilis, Providence species, Pseudomonas species, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus faecalis, when tested in isosensitest agar. The addition of 20% serum to the medium reduced its effectiveness mainly against Providence species, Proteus species, and Streptococcus faecalis. However, the potential for this solution as a bladder instillation or topical antiseptic should be considered because of its reduced side effects compared with chlorhexidene alone, and its increased general effectiveness against all isolates tested.

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