Effect of chlorhexidine/EDTA/Tris against bacterial isolates from clinical specimens
Harper WE, Epis JA.
Department of Microbiology, Royal Perth Hospital, Western Australia.

Chlorhexidine/EDTA/Tris was more active compared with chlorhexidine against the following species of organisms: Acinetobacter species, Citrobacter species, Enterobacter species, Escherichia coli, Proteus mirabilis, Providence species, Pseudomonas species, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus faecalis, when tested in isosensitest agar. The addition of 20% serum to the medium reduced its effectiveness mainly against Providence species, Proteus species, and Streptococcus faecalis. However, the potential for this solution as a bladder instillation or topical antiseptic should be considered because of its reduced side effects compared with chlorhexidine alone, and its increased general effectiveness against all isolates tested.

Publication Types:

• Research Support, Non-U.S. Gov't

MeSH Terms:

• Bacteria/drug effects*
• Bacteria/growth & development
• Bacteria/isolation & purification
• Chlorhexidine/pharmacology*
• Drug Combinations
• Edetic Acid/pharmacology*
• Humans
• Tromethamine/pharmacology*
• Wound Infection/microbiology

Substances:

• Drug Combinations
• Chlorhexidine
• Edetic Acid
• Tromethamine

Paraplegia. 1983 Apr;21(2):86-93.

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