TrizEDTA / TrizEDTA PLUS .15% Chlorhexidine
Evaluation of the in vivo effects of Tris-EDTA and chlorhexidine digluconate 0.15% solution in chronic bacterial otitis externa: 11 cases
Authors: G. Ghibaudo; L. Cornegliani; P. Martino
Source: Veterinary Dermatology, Volume 15, Supplement 1, August 2004 , pp. 65-65(1)
Publisher: Blackwell Publishing
Abstract:
The objectives of this study were to evaluate in vivo tolerance, and antimicrobial
and clinical activities of a topical otic preparation containing EDTA tromethamine
(Tris) and chlorhexidine digluconate 0.15% solution (availabale commercially
as TrizEDTA Plus, DermaPet) in dogs with chronic bacterial otitis externa. Eleven
dogs were included. The affected ears were filled with the solution once daily
during a 2-week period. Dogs were evaluated on days 0, 14 and 28. Three clinical
parameters (exudate, erythema, pain) and three cytologic parameters (Malassezia,
cocci, rods) were scored (0–4 scale) by otoscopic and cytological examinations
of otic exudate. Bacterial cultures were performed at each time point. If there
were bacteria on cytological examination on day 14, the dogs were treated with
the original product, with the addition of enrofloxacin (5%) applied 10 min
after the original product, for a further 2 weeks. All 11 cases yielded isolates
of resistant gram-negative bacteria; gram-positive bacteria were also isolated
from six of 11 dogs. On day 14, six of 11 dogs were negative on culture examination;
on day 28, 10 of 11 were negative and only one case had a positive culture.
On day 14, clinical and microbial scores (cytology) were reduced by 54.6 and
71.1%, respectively, and by 85.7 and 94% on day 28. All cases reported good
tolerance of the treatment. The results show that this ear solution was helpful
in the management of chronic bacterial otitis externa in dogs and was well tolerated.
There seems to be a synergistic effect of the combination of Tris-EDTA/chlorhexidine
digluconate 0.15% solution, and an antimicrobial agent (enrofloxacin) against
resistant gram-positive and gram-negative bacteria.
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