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February 2004
See Ya In Vegas At Booth 517/ MIC Made Easy
DermaPet will NEVER send an attachment. Although we are relatively
sure we are not infected right now, realistic experience tells us to err on
the side of caution, so do not open an email from dermapet@aol.com
if there is an attachment.
Table of Contents
Yada, Yada, Yada
Job Opportunity Filled
How To Use MIC Information To Make Therapeutic
Decisions
EICOSADERM Is Now Available In A 32 Ounce Economy Size
Las Vegas
The Western States conference exhibits open on 2/16 and stay open until 2/19.
We will be greeting people at Booth 517. (Ed note: this is a worldwide newsletter.
Please forgive us sending an announcement
to those of you who are unable to visit what many believe to be the most well
attended meeting in the world.)
The following story was sent to me from LAURA PINALES (Houlton, Maine).This
is the story of Buddy’s mouth. Buddy came to our clinic on Christmas eve.
He had been treated by another vet for 10 months. He had numerous ulcers on
his gums, ropy saliva and breath that could gag a maggot. He was not the most
popular creature in his house and his owners were upset that the house smelled
like Buddy breath rather than Christmas trees and homemade cookies. Previous
treatment had been with various ab's, cautery with iodine, etc. We diagnosed
Chronic Ulcerative Proliferative Stomatitis. He was given injections of depomedrol
under the ulcers after his teeth were cleaned. Appropriate (resp to culture)
ab's were dispensed and DENTACETIC WIPES to control his allergy to his own tartar.
The family has had a good holiday season, Buddy is again appreciated and loved.
We have several new clients.This is a small town and Buddy's owners were some
of the big wigs. Every one wants DENTACETIC WIPES now.
JAY MAIDEN has accepted the job as the Southeast Territory Manager. It was
Edward Bennett Williams who hired George Allen to coach a Washington Redskins
team dubbed the Over-the-hill-gang. Williams said of Allen, who was never one
to trust an inexperienced player, “I gave him an unlimited budget and he
exceeded it.” It has appeared to some that our fearless VP of Sales, JACK
WHITE, has more in common with George Allen than he knows. CHUCK MICHAELS (NE),
COLIN FERGUSON (Central States), PATRICK RAYBURN (SW) AND JOYCE HEFLIN (WEST),
make up the rest of the DermaPet outside sales force. For the TM nearest you
please email, look at our web site or call us.
How To Use MIC Information To Make Therapeutic Decisions
By LOU GOTTHELF
In order to insure that the correct oral dose of Enrofloxacin is being used
to treat a Pseudomonas infection, the endpoint MIC needs to be known. Dr. GBADAMOSI
at Tuskegee (334-727-8940, gbadam@tusk.edu) is computing these for as little
as $18. Endpoint MIC is the lowest concentration of an antibiotic that will
effectively prevent growth of the organism. It is important that there is at
least 8
times the MIC that can be achieved in tissue to kill all of the organisms. This
is called the Inhibitory Quotient (IQ).
With the MIC known, look at the drug insert to find the Cmax of the drug at 2 hours. The Cmax is the level of antibiotic in a particular tissue at various times after either oral or percutaneous administration. For the external ear (which is skin) the Cmax for enrofloxacin is 0.66 mcg/g at the dose of 2.5 mg/kg ( THERESE DeMANUELE showed that in severely inflammed skin or ears that Cmax can be doubled) . If the lab reports the MIC for the Pseuudomonas is 0.25mcg/ml (sensitive) then the calculation is as follows:
IQ=Cmax/MIC
IQ=0.66/.25
IQ=2.64
This is less than the preferred IQ of 8, so this would be an ineffective dose
of enrofloxacin. To achieve the desired IQ of 8, 3 times the 2.5mg dose would
be required (8/2.64=3.03) or a 7.5 mg/kg dose of
enrofloxacin.
In the case of a resistant organism with an MIC of 1.5 mcg/ml or greater, extremely high oral or parenteral doses of enrofloxacin are required, which are almost impossible to achieve without toxicity. In that case topically applied enrofloxacin would be a better choice to achieve the desired Inhibitory Quotient. For example,
IQ=Cmax/MIC
IQ=.66/1.5
IQ=0.44
To achieve an IQ of 8, 18 times (8/.44) the 2.5 mg/kg dose would be required
or 47mg/kg of Enrofloxacin. This is impractical orally or by injection, so topical
therapy would be necessary.
Ed note: TrizEDTA synergizes most antibiotics by mechanisms and a protocol described
in other newsletters and found in various places at http://www.dermapet.com.
EicosaDerm is now available in a 32 ounce economy size. Buy 3 get 1 FREE for the Introductory Special (net $18.99/ less than $0.02/10 lb dose). This will afford 960 doses for a 10 pound dog (or 96 for the 100 pound beast), making this much more affordable than the “one major supplier of omega 3 liquid” and generic caps. In fact, the 32 oz size is about ½ price of 3V liquid HP
“GERIATRICS & GERONTOLOGY” of the Dog and Cat, 2nd Ed., JOHNNY
HOSKINS, published by Elsevier, is out including my chapter “Ear Diseases
and Altered Hearing.”
Back to top
1st Quarter Special. “Dental Month”
EicosaDerm. BUY 10 and get 2 FREE of the 8 ounce size and Buy 3 get 1 free of our new 32 Ounce Economy size.
DentAcetic. Buy 12 Get 12 FREE
Gallons. Buy 3 and Get 1 FREE.
Call your DermaPet Distributor or 800 755 4738 for ordering information.
DermaPet Vision Statement
To be recognized as the leader in developing new and innovative, all natural
yet highly effective products for the veterinary community.
DermaPet Mission Statement
To contribute to your growth and that of the veterinary industry by providing
excellent, unique, innovative all natural yet highly effective products that
embrace the pet, veterinarian, and client relationship.
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DermaPet IS the largest veterinary dermatological company in "virtual
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and the fastest growing. Our Newsletter list, now approaching 18,000, is the
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Steve Melman VMD
http://www.dermapet.com
dermapet@aol.com
800-555-4738 US order line
301-983-8387 outside US
301-365-0191 fax
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Archive of Newsletters
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| Steven Melman VMD DermaPet Animal Dermatology and Behavior Clinics Potomac, MD 20854 |
dermapet@aol.com http://www.dermapet.com 800-755-4738 fax 301-365-0191 |
8909 Iverleigh Court 
Potomac, Maryland
20854
301-983-8387 800-755-4738 Fax 301-365-0191
E-mail dermapet@aol.com
