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October 2005
TrizEDTA Reclarified
DermaPet will NEVER send an attachment. Although we are relatively
sure we are not infected right now, realistic experience tells us to err on
the side of caution, so do not open an email from dermapet@aol.com
if there is an attachment.
Table of Contents
MalAcetic Otic Now Available In 8 Ounce Size
Eicoscaps New Name For OFA Caps Plus EZ-C and Garlic
Meetings
Territory Managers
Specials
DermaLyte Is the New Name for DermaHypoCs
BERNIE KOUMA Named As PetCARE TV President
Release of MalAcetic HC Shampoo, MalAcetic HC Conditioner and MalAcetic HC Wet Wipes
Lou Gotthelf's Small Animal Ear Diseases
TrizEDTA Reclarified
The efficacy and stability of TrizEDTA needs to be reclarified. In the study
by LOU GOTTHELF and GBADAMOSI (see text below) that was presented at an ACVD/AAVD
meeting, Aqueous TrizEDTA needed to be diluted 8x to allow PSEUDOMONAS, previously
cultured as resistant to fluoroquinolones, to just grow. Keep in mind that there
may be misinformation generated, possibly from a competitor with a potentially
ototoxic product containing detergents, alcohol and no USP ingredients. Original
work on tris-edta by Wooley et al was using an aqueous product, without further
preservative, which has remarkable stability; TrizEDTA has 3 year label dating.
Evaluation of the IN VITRO Effect of TrizEDTA on the Minimum Inhibitory Concentration (MIC) of Enrofloxacin Against Ciprofloxacin Resistant PSEUDOMONAS Aeruginosa. GOTTHELF L and Gbadamosi S (AAVD presentation)
This study examined the in vitro effect of TrizEDTA on the minimum inhibitory
concentration (MIC) of enrofloxacin (ENRO) against 12 strains of ciprofloxacin-resistant
Pseudomonas aeruginosa. The bacterial strains were resistant to ciprofloxacin
(MIC>2 µg/ml, and 5 µg/ml disks). Minimally passaged cultures
of the bacterial strains were grown on nutrient agar, and suspended in 50 mM
tris hydrochloride solution at a concentration equivalent to 0.5 McFarland turbidity
standard, optical density(OD) range of 0.08 to 0.10 according to the National
Committee for Clinical Laboratory Standard (NCCLS) recommendation. To determine
the endpoint MIC, the bacterial suspensions were incubated at 37º C for
30 minutes, and were then transferred into wells of microtiter plates containing
two-fold dilutions of ENRO in Mueller-Hinton broth. Following overnight incubation
at 37º C, wells were examined to determine the endpoint MIC of ENRO against
each bacterial strain. Bacterial cultures were
resistant to ENRO at endpoint MICs ranging from 227 µg/ml to 7.09 µg/ml
The same protocol was repeated after TrizEDTA exposure for 5 minutes at 37º
C. Susceptibility to ENRO MIC decreased to lower than 1.7 µg/ml for all
strains. These observations were further evaluated using 10X bacterial concentrations
with similar results. These findings suggest that TrizEDTA exhibits a sparing
in vitro effect on the MIC of enrofloxacin against ciprofloxacin resistant Pseudomonas
aeruginosa and may benefit treatment of otitis externa infections with both
susceptible and resistant Pseudomonas bacteria.
And, otic products are the #1 reason pet-owners re-visit the vet clinic and/or
visit for an OTC product (Vet Economics).
K-9 Influenza Strikes NYC
The Animal Health Diagnostic Center at Cornell has reason to believe that canine
influenza virus is now present in the New York City area. Reports have been
received indicating an unusual form of "kennel cough" has been seen
in a number of veterinary practices. Six animals recovering from this clinical
presentation are all serologically positive for canine influenza virus. Previous
tests of New York State dogs have all been negative.
Canine influenza virus is a relatively new finding in dogs. It was first identified
in racing greyhounds and this virus appears to have been the cause of significant
respiratory problems on the tracks throughout the US for the last 5-6 years.
The Virology Lab at Cornell isolated the first influenza virus from an animal
that died from the infection. The virus was sequenced at CDC and was found to
be closely related to equine influenza virus. Evidence of infection of non-greyhounds
by influenza virus has been found in Florida for the past year.
Yada, Yada, Yada
BRUCE PETERSON, principal at Columbus Serum, accepted an open invitation and
visited for a Washington Nats-San Francisco Giants baseball game. We were treated
to terrific weather and a home team victory while talking as little about business
as conceivable. Other distributors should please feel personally welcome to
visit DermaPet anytime, especially around a sporting event. Just call JACK or
the corporate office.
TVMA, Ft Worth
Considering the washout from hurricane Rita and the evacuation of so much
of SE Texas, the meeting went well. JACK WHITE and PATRICK RAYBURN manned the
show.
Rita hit Texas during the TVMA show.
PENN Dean Kelly Farewell Dinner
JESSICA and I attended to pay our respects to ALAN KELLY who skillfully
and with popularity guided PENN through many years. We wish him luck in post
dean life.
Fatty acids usage needs to be clarified. Current thinking has omega 3 fatty acids being recommended for inflammation of any tissue. The dose of 180 mg EPA/120 DHA per 10 pounds of pet is still the current recommendation. Of course, we are quite fortunate to have EICOSADERM, which is the only ethical veterinary product to offer precisely that dose. Clients do have the option to go to the pharmacy to purchase a generic fish oil cap, although giving 1 cap for every 10 pounds can lead to a memorable experience when dosing an uncooperative, perhaps, fractious pet. And, the dose is DAILY.
Our flagship product, MalAcetic Otic, is now available in a convenient to use,
economical 8 ounce size. Please look at our OTOLOGY ad on our web site
We had a vet call to tell us about using TrizEDTA for calcifying keratitis.
It is suggested to add an appropriate antibiotic such as gentocin and gas sterilize.
The TrizEDTA will chelate the minerals as well as synergize the antibiotic.
I first heard of this from KIRK GELATT.
Eicoscaps New Name For OFA Caps Plus EZ-C and Garlic
EICOSACAPS will be the new name for the OFA Caps Plus EZ-C and garlic. This is our omega 3/6 version very similar to DermCaps except we also have the antioxidants (Vitamins E and C) plus zinc and garlic
We are proud to announce KlearWax, a potent cerumenolytic, degreasing, dewaxing product containing Dioctyl Sodium Sulfosuccinate (DSS) and Urea Peroxide. DSS emulsifies wax and debris. Urea Peroxide is a foaming agent to break up larger clumps of debris. This product is recommended for in house cleansing to clear away debris enabling better visualization of the otic canal and TM. It is available in a 4 ounce size in an applicator bottle.
KlearWax is DermaPet's 5th OTOLOGICAL product. They are (1) MalAcetic Otic, (2) MalAcetic Wet Wipes, (3)MalAcetic HC, (4) TrizEDTA and (5)KlearWax. Many people do not realize that DermaPet has global distribution and is now recognized as the market leader in Otology. Plus we have more coming.
We will be at the WWVC in RENO Oct 6-9 and ATLANTIC CITY at the ACVC, Oct 18-20
MedRx is offering CE
with EAR Seminars by LOU GOTTHELF. They will be in CHICAGO (10-2), SAN DIEGO
(10-23) ALBANY (11-6) and HOUSTON (11-13).
For more information call 888-392-1234 to find out when one is coming near you.
MARK JENSEN can be reached at 949-606-5210 or mjensen716@aol.com. He handles the Far West S CA, AZ, NV.
Al LINGUA will handle the NE from New Jersey north. Al can be reached at 860-810-7280 or ajlingua@aol.com.
KIM CAREY is responsible for the NW from Santa Cruz north. Kim can be reached at k_carey59@hotmail.com or 916-276-3539.
JAY MAIDEN is our TM for the SE US. Jay can be reached at 727-560-2325 or jaymaiden@verizonmail.com.
COLIN FERGUSON is our Midwest rep. He can be reached at 614-539-9176, cferguso@columbus.rr.com.
The "old work-horse" CHUCK MICHAELS (MidAtlantic TM) and PATRICK RAYBURN (SW TM) ducks2003@cox.net continue to ride with distributor reps.
All our sales are guided by the capable JACK WHITE jag6410@aol.com or call 866-DERMAPET. For the TM nearest you please email, look at our web site or call us.
4th Quarter Special Starts 10-1
Buy 3 totally different (not just a different size of the same product) otic
products and get a 4th unpurchased product free or a case of shampoo. You can
buy any size, but, it must be 3 different products. For example, 1 case of MalAcetic
HC, 1 case of MalAcetic Otic and 1 case of
KlearWax and get 1 case of MalAcetic
Wet Wipes. The least expensive case is FREE. Or instead of the 4 the Otic
add a case of a Shampoo product.
Gallons. Buy 3 and Get 1 FREE.
EicosaDerm is now available in a 32 ounce economy size
Call your DermaPet Distributor or 800 755 4738 for ordering information.
DermaLyte Is the New Name for DermaHypoCs
DermaLyte is the new name for DermaHypoCs.
DermaLyte is our original hypoallergenic shampoo which contains no animal protein,
soap, dyes or fragrances. DermaLyte, available in 8 oz and gallons, is in our
new clear bottles with the purple caps.
BERNIE KOUMA Named As PetCARE TV President
PetCARE TV has named BERNIE KOUMA as president and announced two new Veterinary
Advisory Board Members: TOM CATANZARO JAN BELLOWS. In addition to its popular
sponsored Reception Room Client Education System, PetCARE TV has introduced
the Welcome Home Your New Friend DVD. This DVD for new pet owners is actually
a "pet owner’s manual" that deals with early behavior problems,
the importance of completing the entire series of initial immunizations, as
well as "partnering" with their veterinarian for the benefit of their
new pet. For a FREE sample of both DVDs e-mail Melody at mjurgens@petcaretv.com.
Release of MalAcetic HC Shampoo, MalAcetic HC Conditioner and MalAcetic HC Wet Wipes
Coming soon, we will release MalAcetic HC Shampoo, MalAcetic HC Conditioner and MalAcetic HC Wet Wipes. The Conditioner is a leave-on, dry-on product. All MalAcetic HC products retain their antimicrobial efficacy (See New Treatment of Malassezia Otitis, Gotthelf, Vet Forum, 7/97; Efficacy of an Acetic Acid/Boric Acid Ear Cleaning Solution for Treatment and Prophylaxis of Malassezia sp. Otitis Externa Aust Vet Pract 34[2]:79-82 Jun'04 http://www.dermapet.com/articles/efficacy.pdf and Susceptibility of Selected Otitis Externa Pathogens to Individual and Mixtures of Acetic and Boric Acids, Benson CE, Proc 14th AAVD/ACVD meeting, 1998).
I invite you to read all of the above articles at our web site. In particular, note that MalAcetic is 87% and 88% effective against Malassezia and, at .5% MalAcetic is effective against Staphylococcus while at 1% is effective against Pseudomonas. Note: that the 2% strength provided by our MalAcetic Otic and the rest of the MalAcetic line is what you have been relying upon. Now, for those sensitive, inflamed, pruritic or erythematous cases, you can use a gentler product with hydrocortisone.
Lou Gotthelf's Small Animal Ear Diseases
Lou Gotthelf's Small Animal Ear Diseases 2nd Ed is out. There is a chapter by YT as well as many others. At $59.95 this is a great deal considering all the color photos and the fact that ears represent up to 20% of your business.
DermaPet Vision Statement
To be recognized as the leader in developing new and innovative, all natural
yet highly effective products for the veterinary community.
DermaPet Mission Statement
To contribute to your growth and that of the veterinary industry by providing
excellent, unique, innovative all natural yet highly effective products that
embrace the pet, veterinarian, and client relationship.
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Steve Melman VMD
http://www.dermapet.com
dermapet@aol.com
800-555-4738 US order line
301-983-8387 outside US
301-365-0191 fax
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Archive of Newsletters
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| Steven Melman VMD DermaPet Animal Dermatology and Behavior Clinics Potomac, MD 20854 |
dermapet@aol.com http://www.dermapet.com 800-755-4738 fax 301-365-0191 |
8909 Iverleigh Court 
Potomac, Maryland
20854
301-983-8387 800-755-4738 Fax 301-365-0191
E-mail dermapet@aol.com